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19 November 2007 Optical Doppler tomography with short-time Fourier transform and Hilbert transform
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Optical Doppler tomography (ODT) combines Doppler principle with Optical coherence tomography (OCT) to image both the structure and the flow velocity of moving particles in highly scattering biological tissues. The flow velocity can be determined by measurement of the Doppler shift of the interference fringe frequency with a short-time Fourier transform (STFT) or a Hilbert transform. For STFT ODT, velocity resolution varies inversely with the Fourier transform window size at each pixel, while spatial resolution is proportional to the window size. Consequently, velocity resolution and spatial resolution are coupled. For phase-resolved ODT with Hilbert transform, high velocity resolution can be achieved while maintaining a high spatial resolution. However, the maximum determinable Doppler shift is limited by axial-line scanning speed. As a result, STFT ODT and phase-resolved ODT are applicable to measurement of high speed and low speed velocity, respectively. We use these two methods in the established ODT system. An in vitro model using a small circular glass tubule with flowing solution of polystyrene beads inside and an in vivo model of rat's cerebral arterioles are investigated, demonstrating the advantage and disadvantage of STFT ODT and phase-resolved ODT.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jie Meng and Zhihua Ding "Optical Doppler tomography with short-time Fourier transform and Hilbert transform", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682602 (19 November 2007);

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