Optical microscopy with nanometer resolution for single molecule detection

Guiying Wang; Guo Fu; Chen Wang; Zenghui Zhou; Li Liu; Ruxin Li

doi:10.1117/12.778585

8 January 2008 Optical microscopy with nanometer resolution for single molecule detection

Guiying Wang, Guo Fu, Chen Wang, Zenghui Zhou, Li Liu, Ruxin Li

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 682612 (2008) https://doi.org/10.1117/12.778585
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

Fluorescence microscopies with nanometer-distance resolution to locate the position and track individual single molecules were developed and applied. We focused on quantitatively study of the motion of lipid-anchor green fluorescent proteins with an oblique illumination mode of the microscope. A protein dynamics was analyzed using a photon statistics. In addition, fluorescence resonance energy transfer (FRET) microscopy and surface enhance Ranman spectroscopy (SERS) studies etc. were also introduced in this report .

Citation Download Citation

Guiying Wang, Guo Fu, Chen Wang, Zenghui Zhou, Li Liu, and Ruxin Li "Optical microscopy with nanometer resolution for single molecule detection", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682612 (8 January 2008); https://doi.org/10.1117/12.778585

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