8 January 2008 Progress on noninvasive and minimally invasive methods on transcutaneous blood glucose sensing
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Noninvasive and minimally invasive blood glucose sensing is one of most interesting research fields. For the noninvasive measurement using near-infrared spectroscopy, the optical signal was impaired by the uncertain physiological noise and systematical drift. A floating reference method by differentially processing two signals from reference point and measuring point was used to deal with these uncertain noises. For the minimally invasive measurement, interstitial fluid extracted by ultrasound and vacuum is investigated. Low-frequency ultrasound was applied to enhance the skin permeability to interstitial fluid by disrupting the stratum corneum lipid bilayers. In this paper, a kind of protein absorbing the glucose specifically called D-galactose/D-glucose Binding Protein (GGBP) was introduced to construct a novel surface plasmon resonance (SPR) measuring system. By immobilizing GGBP onto the surface of the SPR sensor, a new detecting system for glucose testing in mixed solution was developed. The experimental result indicated that, the SPR system succeeded in distinguishing glucose resolution of 0. 1 mg/L, and had linear relationship between 0.5 mg/L and 5 mg/L.
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Kexin Xu, Kexin Xu, Rong Liu, Rong Liu, Jin Liu, Jin Liu, Wenliang Chen, Wenliang Chen, Dachao Li, Dachao Li, Zhenhui Du, Zhenhui Du, } "Progress on noninvasive and minimally invasive methods on transcutaneous blood glucose sensing", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682616 (8 January 2008); doi: 10.1117/12.760307; https://doi.org/10.1117/12.760307

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