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8 January 2008Optical properties of core-multishell quantum dots and their imaging applications in cancer cells
Core-shell semiconductor quantum dot (QD) has been attracting more and more extensive attentions and interests in
biomedicine photonics due to its good stability and high fluorescence quantum efficiency. In this paper, we reported that
the photoluminescence of core-multishell CdSe QDs performed a two-photon action under a femtosecond laser
excitation in wide incident power range. The two-photon absorption cross sections of such QDs were measured by the
intensity-dependent transmittance method and the results demonstrated a very strong two-photon absorption capacity of
QDs. The fluorescent spectra of QDs with an amphiphilic polymer showed that the fluorescent peak wavelength
appeared blue shift obviously and the full width at half maximum (FWHM) broadened to 40 nm. Furthermore, the
intracellular distribution of the QDs probes in cancer cells had been observed under two-photon excitation. The
experimental results indicated that the QDs mainly distribute at cell membrane and selectively gathered on cytoplasm of
cancer cells. The QDs which permeated into cancer cells quickly were very steady binding with cancer cells. Under long
time laser irradiation, the QDs hardly took place photobleaching, which demonstrated a very steady photochemical
performance of these QDs..
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Y. Liu, P. Chen, L. Lin, G.-Q. Tang, G.-G. Mu, "Optical properties of core-multishell quantum dots and their imaging applications in cancer cells," Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261H (8 January 2008); https://doi.org/10.1117/12.757443