Optical properties of core-multishell quantum dots and their imaging applications in cancer cells

Y. Liu; P. Chen; L. Lin; G.-Q. Tang; G.-G. Mu

doi:10.1117/12.757443

Abstract

Core-shell semiconductor quantum dot (QD) has been attracting more and more extensive attentions and interests in biomedicine photonics due to its good stability and high fluorescence quantum efficiency. In this paper, we reported that the photoluminescence of core-multishell CdSe QDs performed a two-photon action under a femtosecond laser excitation in wide incident power range. The two-photon absorption cross sections of such QDs were measured by the intensity-dependent transmittance method and the results demonstrated a very strong two-photon absorption capacity of QDs. The fluorescent spectra of QDs with an amphiphilic polymer showed that the fluorescent peak wavelength appeared blue shift obviously and the full width at half maximum (FWHM) broadened to 40 nm. Furthermore, the intracellular distribution of the QDs probes in cancer cells had been observed under two-photon excitation. The experimental results indicated that the QDs mainly distribute at cell membrane and selectively gathered on cytoplasm of cancer cells. The QDs which permeated into cancer cells quickly were very steady binding with cancer cells. Under long time laser irradiation, the QDs hardly took place photobleaching, which demonstrated a very steady photochemical performance of these QDs..

Citation Download Citation

Y. Liu, Y. Liu, P. Chen, P. Chen, L. Lin, L. Lin, G.-Q. Tang, G.-Q. Tang, G.-G. Mu, G.-G. Mu, } "Optical properties of core-multishell quantum dots and their imaging applications in cancer cells", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261H (8 January 2008); doi: 10.1117/12.757443; https://doi.org/10.1117/12.757443

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