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8 January 2008 Multifunctional nanoprobe for biological applications based on surface enhanced Raman scattering
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Abstract
Optical probes are now routinely used in a remarkable number of imaging applications in the life sciences and medicine. We report the design, synthesis and characterization of a novel nanoprobe for biological applications based on surface enhanced Raman scattering (SERS). Specifically, the nanoprobe consists of magnetic Fe3O4 nanoparticles immobilized with silver nanoparticles and SERS tags. An efficient cellular uptake has been confirmed with confocal laser scanning microscopy. The nanoprobe retains its excellent SERS signals when incorporated into a cell. Besides, the probe also delivers spatially localized chemical information from its biological environments. The multi-functional probe is likely to be useful to develop new tools for targeted molecular probing of cells and provide a new way to monitor the complex changes at cellular level.
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Zhuyuan Wang, Changgui Lu, Binfeng Yun, Guohua Hu, and Yiping Cui "Multifunctional nanoprobe for biological applications based on surface enhanced Raman scattering", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261I (8 January 2008); https://doi.org/10.1117/12.757769
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