Comparison between HMME mediated photodynamic therapy using 413nm and 532nm for port wine stains: a mathematical simulation study

Y. Wang; Y. Gu; R. Chen; L. Q. Xu; X. H. Liao; N. Y. Huang; Y. Y. Wang

doi:10.1117/12.755783

8 January 2008 Comparison between HMME mediated photodynamic therapy using 413nm and 532nm for port wine stains: a mathematical simulation study

Y. Wang, Y. Gu, R. Chen, L. Q. Xu, X. H. Liao, N. Y. Huang, Y. Y. Wang

Author Affiliations +

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68261L (2008) https://doi.org/10.1117/12.755783
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

Introduction: As it is always difficult to find the optimal combination of photosensitizer and of laser wavelength to achieve selective vascular damage in PWS-PDT, the selective vascular effects of HMME (Hematoporphyrin monomethyl ether) mediated PDT with 413 nm and with 532 nm were compared by mathematical simulation in this study. Materials & Methods: Firstly, distribution of 413 nm, 532 nm light in PWS tissue was simulated by Monte Carlo model. Two energy density groups were set, one is 80mW/cm²x40min for both 413 nm and 532 nm, the other is 80mW/cm²x40min for 532 nm while 80mW/cm²x20min in for 413 nm. Secondly, the productivity of reactive oxygen species (ROS) in target vessels and normal tissue were simulated using a simulation system for PDT of PWS established in our lab, which considering the amount of light and photosensitizer in tissue, the molar extinction coefficient of photosensitizer, and quantum yield of ROS. Concentration of HMME for each wavelength were same. Finally, the productivity of ROS n in target vessels and normal tissue were compared between 413 nm PDT and 532 nm PDT under different energy density. Result: Under the same energy density, ROS productivity in target vessels of 413 nm PDT was significantly higher than that of 532 nm PDT. Moreover, it was still higher at low energy density than that of 532nm PDT with high energy density. Conclusion: HMME mediated PDT using 413 nm has the potential to increase the selective vascular effect of PDT for PWS by shortening treatment time.

Citation Download Citation

Y. Wang, Y. Gu, R. Chen, L. Q. Xu, X. H. Liao, N. Y. Huang, and Y. Y. Wang "Comparison between HMME mediated photodynamic therapy using 413nm and 532nm for port wine stains: a mathematical simulation study", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261L (8 January 2008); https://doi.org/10.1117/12.755783

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