8 January 2008 Nonlinear optical microscopy of bronchus
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As the first barrier exposed to carcinogens, the bronchus is prone to early pathologic alterations. The assessment of these early changes is of key significance in the physiological studies and disease diagnosis of bronchus. Here, we demonstrate nonlinear optical microscopy (NOLM) to image mouse bronchial wall microstructure based on intrinsic nonlinear optical contrast. Our results show that NOLM is effective for imaging the bronchial intact microstructural components, providing quantitatively information on the biomorphology and biochemistry of tissue. With the advent of the clinical portability of typical nonlinear optical endoscopy, the NOLM technique has the potential to be applied in vivo the clinical diagnosis and monitoring of bronchial disease.
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Shuangmu Zhuo, Shuangmu Zhuo, Jianxin Chen, Jianxin Chen, Xingshan Jiang, Xingshan Jiang, Shusen Xie, Shusen Xie, Huanglin Chen, Huanglin Chen, Rong Chen, Rong Chen, } "Nonlinear optical microscopy of bronchus", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261T (8 January 2008); doi: 10.1117/12.755221; https://doi.org/10.1117/12.755221

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