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19 November 2007 Near-infrared Raman spectroscopy for optical diagnosis of gastric precancer
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Raman spectroscopy is a molecular vibrational spectroscopic technique that is capable of optically probing the biomolecular changes associated with diseased transformation. The purpose of this study was to explore near-infrared (NIR) Raman spectroscopy for identifying precancer (dysplasia) from normal gastric mucosa tissues. High-quality Raman spectra in the range of 800-1800 cm-1 can be acquired from gastric tissue within 5 seconds. Raman spectra showed significant differences between normal and dysplastic tissue, particularly in the spectral ranges of 850-900, 1,200-1,290 and 1,500-1,800 cm-1 which contained signals related to hydroxyproline, amide III and amide I of proteins, and C=C stretching of lipids, respectively. The ratio of Raman intensities at 875 to 1,450 cm-1 provided good differentiation between normal and dysplastic gastric tissue (unpaired Students' t-test, p<0.001), indicating that NIR Raman spectroscopy has a great potential for the non-invasive diagnosis of dysplasia in the stomach.
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Seng Khoon Teh, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, and Zhiwei Huang "Near-infrared Raman spectroscopy for optical diagnosis of gastric precancer", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682625 (19 November 2007);

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