Preliminary study on Raman spectra of nasopharyngeal carcinoma in vitro

Yongzeng Li; Rong Chen; Jianji Pan; Shangyuan Feng; Guannan Chen; Wei Huang; Wenshuo Lin

doi:10.1117/12.756645

8 January 2008 Preliminary study on Raman spectra of nasopharyngeal carcinoma in vitro

Yongzeng Li, Rong Chen, Jianji Pan, Shangyuan Feng, Guannan Chen, Wei Huang, Wenshuo Lin

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 682627 (2008) https://doi.org/10.1117/12.756645
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

Nasopharyngeal carcinoma (NPC) is one of the malignant tumors threatening people's health and life which is mostly found in South China; early diagnosis is crucial to improve the effective treatment and higher survival rates. In this work, preliminary study on Raman spectra of nasopharyngeal carcinoma in vitro is reported. Spectra were obtained from normal and cancerous nasopharyngeal tissue which had undergone biopsy for high risk nasopharyngeal carcinoma. Factors effecting Raman spectra were also studied including sample storage time, spectral accumulation time. The results show that sample storage time has a negative effect on the measurement while increasing accumulation time does not appear to improve the spectra quality significantly. Consistent spectral differences appear to exist between normal and cancerous tissues, mainly in several bands. The results demonstrate Raman spectroscopy has the potential ability to detect and diagnose cancerous tissues. Future studies will advance toward true in vivo, real time and non-invasively.

Citation Download Citation

Yongzeng Li, Rong Chen, Jianji Pan, Shangyuan Feng, Guannan Chen, Wei Huang, and Wenshuo Lin "Preliminary study on Raman spectra of nasopharyngeal carcinoma in vitro", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682627 (8 January 2008); https://doi.org/10.1117/12.756645

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