The evaluation of the photoaging of the human skin by three-dimensional polarization sensitive spectral domain optical coherence tomography

Arata Miyazawa; Shingo Sakai; Masayuki Matsumoto; Noriaki Nakagawa; Masahiro Yamanari; Yoshiaki Yasuno

doi:10.1117/12.762674

8 February 2008 The evaluation of the photoaging of the human skin by three-dimensional polarization sensitive spectral domain optical coherence tomography

Arata Miyazawa, Shingo Sakai, Masayuki Matsumoto, Noriaki Nakagawa, Masahiro Yamanari, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 684207 (2008) https://doi.org/10.1117/12.762674
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Noninvasive evaluation of dermal degeneration is important for a diagnosis of photoaging. Polarization sensitive optical coherence tomography (PS-OCT) can measure the distribution of phase retardation caused by birefringence property of collagen. The PS-OCT has been reported as the technology of in vivo investigation of collagen structure in the skin. PS-spectral domain (SD)-OCT provides a three-dimensional phase retardation volume, and it provides an en face distribution map of the slopes of cumulative phase retardation. In this research, we measured the lateral orbital area and forehead of 7 young (age = 24.7±1.1) and 6 elder (age = 72.5±1.4) volunteers by a custom-built 840 nm fiber based PS-SD-OCT. This system can measure the skin birefringence three-dimensionally (5.5 sec for a 3-D volume). There was a significant difference in mean of the distribution of phase retardation slopes of the lateral orbital area between young and old cohorts (young: 0.356±0.0255 degree/μm; elder: 0.256±0.0118 degree/μm). However, there was no significant difference in forehead. On the other hand, the shapes of histogram was not normal distribution. Therefore, we calculated skewness and kurtosis of the distributions of slopes for the analysis. In the orbital area, there were also significant differences between young and old cohorts in skewness (y: 0.813±0.135; e: 1.51+/- 0.177) and kurtosis (y: 2.85±0.483; e: 5.23±0.862). In forehead, there was a significant difference between young and old cohorts in skewness (p=0.0289) in contrast with mean (p= 0.065).

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Arata Miyazawa, Shingo Sakai, Masayuki Matsumoto, Noriaki Nakagawa, Masahiro Yamanari, and Yoshiaki Yasuno "The evaluation of the photoaging of the human skin by three-dimensional polarization sensitive spectral domain optical coherence tomography", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684207 (8 February 2008); https://doi.org/10.1117/12.762674

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KEYWORDS

Collagen

Skin

Birefringence

Optical coherence tomography

Polarization

Statistical analysis

Phase measurement

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