Tumor necrosis factor-alpha induced enhancement of cryosurgery

Raghav Goel; Guilio F. Paciotti; John C. Bischof

doi:10.1117/12.764020

25 February 2008 Tumor necrosis factor-alpha induced enhancement of cryosurgery

Raghav Goel, Guilio F. Paciotti, John C. Bischof

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 68420R (2008) https://doi.org/10.1117/12.764020
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Local recurrence of cancer after cryosurgery is related to the inability to monitor and predict destruction of cancer (temperatures > -40°C) within an iceball. We previously reported that a cytokine adjuvant TNF-α could be used to achieve complete cancer destruction at the periphery of an iceball (0 to -40°C). This study is a further development of that work in which cryosurgery was performed using cryoprobes operating at temperatures > -40°C. LNCaP Pro 5 tumor grown in a dorsal skin fold chamber (DSFC) was frozen at -6°C after TNF-α incubation for 4 or 24 hours. Tumors grown in the hind limb were frozen with a probe tip temperature of -40°C, 4 or 24 hours after systemic injection with TNF-α. Both cryosurgery alone or TNF-α treatment alone caused only a minimal damage to the tumor tissue at the conditions used in the study. The combination of TNF-α and cryosurgery produced a significant damage to the tumor tissue in both the DSFC and the hind limb model system. This augmentation in cryoinjury was found to be time-dependent with 4-hour time period between the two treatments being more effective than 24-hour. These results suggests the possibility of cryotreatment at temperatures > -40°C with the administration of TNF-α.

Citation Download Citation

Raghav Goel, Guilio F. Paciotti, and John C. Bischof "Tumor necrosis factor-alpha induced enhancement of cryosurgery", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420R (25 February 2008); https://doi.org/10.1117/12.764020

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