Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors

Anil Shetty; Andrew M. Elliott; Jon A. Schwartz; James Wang; Emilio Esparza-Coss; Sherry Klumpp; Brian Taylor; John D. Hazle; R. Jason Stafford

doi:10.1117/12.763160

8 February 2008 Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors

Anil Shetty, Andrew M. Elliott, Jon A. Schwartz, James Wang, Emilio Esparza-Coss, Sherry Klumpp, Brian Taylor, John D. Hazle, R. Jason Stafford

Author Affiliations +

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 68420S (2008) https://doi.org/10.1117/12.763160
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

This study investigates the potential of using gold nanoshells to mediate a thermally induced modulation of tumor vasculature in experimental prostate tumors. We demonstrate that after passive extravasation and retention of the circulating nanoshells from the tumor vasculature into the tumor interstitium, the enhanced nanoshells absorption of near-infrared irradiation over normal vasculature, can be used to increase tumor perfusion or shut it down at powers which result in no observable affects on tissue without nanoshells. Temperature rise was monitored in real time using magnetic resonance temperature imaging and registered with perfusion changes as extrapolated from MR dynamic contrast enhanced (DCE) imaging results before and after each treatment. Results indicate that nanoshell mediated heating can be used to improve perfusion and subsequently enhance drug delivery and radiation effects, or be used to shut down perfusion to assist in thermal ablative therapy delivery.

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Anil Shetty, Andrew M. Elliott, Jon A. Schwartz, James Wang, Emilio Esparza-Coss, Sherry Klumpp, Brian Taylor, John D. Hazle, and R. Jason Stafford "Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420S (8 February 2008); https://doi.org/10.1117/12.763160

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