8 February 2008 Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors
Author Affiliations +
Abstract
Minimally invasive thermal therapy is gaining ground as a new treatment modality of prostate tumors. However, further understanding of molecular events like HSP70 expression is required for treatment planning and coordination with chemotherapy and radiation. Metastatic prostate tumor (PC3 MM2) cells, transduced with reporter genes, were utilized to study the expression of HSP70 induced by normal and nanoshell-mediated heating. A correlation was noted between HSP70 expression, cellular viability and heating temperatures. This imaging paradigm can be developed into a PET-MR thermal treatment regimen, which would include dosimetry planning, real time temperature monitoring and post treatment assessment of tumor response at a cellular level.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Anil Shetty, Amer Najjar, Andrew M. Elliott, Adam Springer, R. Jason Stafford, Ken Diller, Juri Gelovani, John D. Hazle, "Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420T (8 February 2008); doi: 10.1117/12.763361; https://doi.org/10.1117/12.763361
PROCEEDINGS
9 PAGES


SHARE
Back to Top