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25 February 2008 Frequency encoded optical assessment of human retinal physiology
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Proceedings Volume 6844, Ophthalmic Technologies XVIII; 68440I (2008)
Event: SPIE BiOS, 2008, San Jose, California, United States
We demonstrate in-vivo functional imaging of the human retina with Fourier domain optical coherence tomography employing frequency encoding of an excitation pattern. The principle is based on projecting a modulated rectangular pattern across the foveal region and acquiring a time series of B-Scans at the same vertical position across the pattern. The idea is to modulate the excitation with a frequency that is distinct from the heartbeat and irregular motion artifacts. Fourier analysis of the time series at each transverse position in the B-scan series allows assessing the retinal response as change in the FDOCT reflectivity signal exactly at the pattern modulation frequency. We observe a change in retinal reflectivity within the region of the outer segment photoreceptor layer exactly at the pattern modulation frequency.
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Rainer A. Leitgeb, Roland Michaely, Adrian Bachmann, Theo Lassner, and Cedric Blatter "Frequency encoded optical assessment of human retinal physiology", Proc. SPIE 6844, Ophthalmic Technologies XVIII, 68440I (25 February 2008);

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