Dosimetric considerations of interstitial photodynamic therapy of the canine prostate mediated by intra-arterially administered hypocrellin derivative

Weiyang Liu; Dwayne J. Dickey; Zhengwen Xiao; Ronald B. Moore; John Tulip

doi:10.1117/12.783641

11 February 2008 Dosimetric considerations of interstitial photodynamic therapy of the canine prostate mediated by intra-arterially administered hypocrellin derivative

Weiyang Liu, Dwayne J. Dickey, Zhengwen Xiao, Ronald B. Moore, John Tulip

Author Affiliations +

Proceedings Volume 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII; 684519 (2008) https://doi.org/10.1117/12.783641
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Interstitial photodynamic therapy (iPDT) is a promising minimally invasive treatment modality for locally confined prostate cancer. Therapeutically excited at 635nm, the photophysical properties of SL-052 (a novel hypocrellin derivative photosensitizer) lend themselves uniquely to iPDT, facilitating real-time monitoring. Under 635nm excitation, SL-052 exhibits near infrared fluorescence, allowing both photosensitizer fluorescence and tissue transmissivity to be continuously monitored. The absorption and fluorescence characteristics of SL-052 in vivo and in vitro are first illustrated. SL-052 mediated iPDT of canine prostate was performed with a novel switched light delivery system and novel intra-arterial drug delivery method. A preliminary examination of the dosimetric properties of intra-arterial iPDT is presented, focusing on transmissivity dynamics. Spectrofluorimetry results relating specifically to the unique photophysical properties of SL-052 iPDT are also included.

Citation Download Citation

Weiyang Liu, Dwayne J. Dickey, Zhengwen Xiao, Ronald B. Moore, and John Tulip "Dosimetric considerations of interstitial photodynamic therapy of the canine prostate mediated by intra-arterially administered hypocrellin derivative", Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 684519 (11 February 2008); https://doi.org/10.1117/12.783641

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