11 February 2008 Photodynamic therapy (PDT) to treat a chronic skin wound in a dog
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Photodynamic Therapy (PDT) is an emerging and promising therapeutic modality for treatment of a wide variety of malignant and nononcologic tumors, as well as in the treatment of infected skin ulcers. This study evaluated the effectiveness of the PDT to treat a chronic skin wound that had been already subjected to several clinical and surgical type treatments in a dog. The animal with an infected chronic skin wound with 8 cm diameter in the left leg received an injection of an aqueous solution of 1% methylene blue (MB) with 2% lidocaine into the lesion. After MB injection the wound was irradiated using a LED (LED-VET MMOptics(r)) with a wavelength between 600 and 700 nm, 2 cm diameter circular light beam, of 150 mW of power, light dose of 50 J/cm2. After 3 and 6 weeks PDT was repeated and the wound was re-evaluated. Complete healing was achieved 10 weeks after the first procedure.
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Raduan Hage, Raduan Hage, Hélio Plapler, Hélio Plapler, Renata Andrade Bitar, Renata Andrade Bitar, "Photodynamic therapy (PDT) to treat a chronic skin wound in a dog", Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 68450X (11 February 2008); doi: 10.1117/12.761679; https://doi.org/10.1117/12.761679

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