18 February 2008 Spectral density and tissue perfusion from speckle contrast measurements
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Progress in laser and camera technology has simplified the acquisition of laser speckle images relating to dermal blood flow. Using speckle contrast measurements over 5 decades of exposure time, we show that a temporal autocorrelation function, and hence spectral information and a perfusion index precisely equivalent to that produced in Doppler methods, can be derived from speckle measurements. The autocorrelation data are well approximated by a simple but nonexponential function which is parametric in a characteristic time τc. We suggest that the perfusion index could be found simply by determining τc from a small number of speckle measurements at appropriate exposures. This is illustrated by measurement of perfusion recovery following an induced change in perfusion.
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O. B. Thompson, O. B. Thompson, M. K. Andrews, M. K. Andrews, } "Spectral density and tissue perfusion from speckle contrast measurements", Proc. SPIE 6847, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII, 68472D (18 February 2008); doi: 10.1117/12.761453; https://doi.org/10.1117/12.761453

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