Optical coherence microscope for invariant high resolution in vivo skin imaging

S. Murali; K. S. Lee; P. Meemon; J. P. Rolland

doi:10.1117/12.763394

12 February 2008 Optical coherence microscope for invariant high resolution in vivo skin imaging

S. Murali, K. S. Lee, P. Meemon, J. P. Rolland

Proceedings Volume 6849, Design and Quality for Biomedical Technologies; 684903 (2008) https://doi.org/10.1117/12.763394
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

A non-invasive, reliable and affordable imaging system with the capability of detecting skin pathologies such as skin cancer would be a valuable tool to use for pre-screening and diagnostic applications. Optical Coherence Microscopy (OCM) is emerging as a building block for in vivo optical diagnosis, where high numerical aperture optics is introduced in the sample arm to achieve high lateral resolution. While high numerical aperture optics enables realizing high lateral resolution at the focus point, dynamic focusing is required to maintain the target lateral resolution throughout the depth of the sample being imaged. In this paper, we demonstrate the ability to dynamically focus in real-time with no moving parts to a depth of up to 2mm in skin-equivalent tissue in order to achieve 3.5&mgr;m lateral resolution throughout an 8 cubic millimeter sample. The built-in dynamic focusing ability is provided by an addressable liquid lens embedded in custom-designed optics which was designed for a broadband laser source of 120 nm bandwidth centered at around 800nm. The imaging probe was designed to be low-cost and portable. Design evaluation and tolerance analysis results show that the probe is robust to manufacturing errors and produces consistent high performance throughout the imaging volume.

Citation Download Citation

S. Murali, K. S. Lee, P. Meemon, and J. P. Rolland "Optical coherence microscope for invariant high resolution in vivo skin imaging", Proc. SPIE 6849, Design and Quality for Biomedical Technologies, 684903 (12 February 2008); https://doi.org/10.1117/12.763394

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Skin

Image resolution

Tissue optics

In vivo imaging

Microscopes

Skin cancer

Optical coherence tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years