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12 February 2008 Diffuse optical-MRI fusion and applications
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Diffuse optical imaging (DOI) is a relatively new functional imaging modality offering the possibility to record changes in hemoglobin concentrations. It is based on the propagation of near-infrared light through biological tissues. By measuring the optical absorption of the blood in the cortex, DOI enables the estimation of changes of deoxy-hemoglobin (HbR) and oxy-hemoglobin (HbO2) concentrations. It thus provides indirect information on neuronal activity. Drawbacks of optical imaging are its lack of quantification abilities as well as poor spatial resolution. Although not much can be done concerning the second issue, diffusion being the limiting factor, one can aim at more quantitative data by the use of extra information. As an example, the determination of baseline concentrations done by fitting a temporal or frequency curve to recover background concentrations is not expected to be accurate due to the heterogeneity of the underlying tissues. The vascular architecture, unknown when doing DOI alone, also plays a significant role in the signal detected. Partial volume effects due to an optode pair overlapping a large vein will lead to confounding data and create difficulties in analyzing the neuronal activation. Here we show that fusion with MRI, but done outside the scanner, may help solving some of these issues.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
F. Lesage, L. Gagnon, and M. Dehaes "Diffuse optical-MRI fusion and applications", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500C (12 February 2008);

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