12 February 2008 An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique
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Abstract
An image reconstruction scheme for time-domain fluorescence diffuse optical tomography is proposed using a reflection-mode for a semi-infinite turbid geometry. The method is based on a generalized pulse spectrum technique that employs analytic expressions of the Laplace-transformed time-domain photon-diffusion model to construct a Born normalized inverse model, and a pair of real domain transform-factors to separate distributions of the fluorescent yield and lifetime. The methodology is validated with a specifically-developed fluorescent Monte-Carlo simulator or finite-element-based methods and its robustness to the background uncertainties is investigated.
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Huiyuan He, Huiyuan He, Limin Zhang, Limin Zhang, Feng Gao, Feng Gao, Zheng Ma, Zheng Ma, Huijian Zhao, Huijian Zhao, Jingying Jiang, Jingying Jiang, "An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500M (12 February 2008); doi: 10.1117/12.756377; https://doi.org/10.1117/12.756377
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