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14 February 2008 Fluorescence diffuse optical tomography with structural a priori information
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Fluorescence diffuse optical tomography (FT) is an emerging molecular imaging technique that can spatially resolve both fluorophore concentration and lifetime parameters. In this study, we investigated the performance of a frequency domain FT system for inclusions with various sizes and contrast levels. Due to the ill-posedness of the FT problem, the fluorescence parameters can not be recovered accurately. The reconstructed fluorescence parameters depend on the signal to background contrast and size of the compartments containing the fluorophores. Recently, imaging with multiple modalities has become a popular trend. Different modalities give different information on the subject under investigation. Here, we evaluated the improvement in FT reconstruction when structural a priori information from a second imaging modality was incorporated. The results demonstrated that the structural a priori information was crucial to be able to recover both parameters with high accuracy. Without such a priori information, the same fluorophore concentration for different object sizes could not be recovered to the same value. On the other hand, when the structural a priori information was available, both fluorescence parameters could be recovered within 15% error for all the cases.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yuting Lin, Orhan Nalcioglu, and Gultekin Gulsen "Fluorescence diffuse optical tomography with structural a priori information", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500Z (14 February 2008);

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