Correction for source decay in bioluminescence tomography

Mehmet Burcin Unlu; Gultekin Gulsen

doi:10.1117/12.768039

19 February 2008 Correction for source decay in bioluminescence tomography

Mehmet Burcin Unlu, Gultekin Gulsen

Proceedings Volume 6850, Multimodal Biomedical Imaging III; 685010 (2008) https://doi.org/10.1117/12.768039
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Time variation of the bioluminescence source can cause artifacts in the tomographic images. We showed that the a priori knowledge of the light kinetics could be used to eliminate these artifacts. We performed two-dimensional simulations. We considered a 40-mm-diameter circular region with an inclusion of 6-mm-diameter located 10-mm away from the center. The measurement data was simulated using a finite element based forward solver. We modeled the non-contact measurements such that four-wavelength data was collected from four 90-degree-apart views. The results showed that the ratio of the total imaging time to the half-life of the exponentially decaying bioluminescent source was the deciding factor in the reconstruction of the source. It was also demonstrated that a priori knowledge of the source kinetics was required to perform tomographic bioluminescence imaging of short half-life bioluminescent sources and the use of spatial a priori information alone was not adequate.

Citation Download Citation

Mehmet Burcin Unlu and Gultekin Gulsen "Correction for source decay in bioluminescence tomography", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 685010 (19 February 2008); https://doi.org/10.1117/12.768039

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available