19 February 2008 Correction for source decay in bioluminescence tomography
Author Affiliations +
Abstract
Time variation of the bioluminescence source can cause artifacts in the tomographic images. We showed that the a priori knowledge of the light kinetics could be used to eliminate these artifacts. We performed two-dimensional simulations. We considered a 40-mm-diameter circular region with an inclusion of 6-mm-diameter located 10-mm away from the center. The measurement data was simulated using a finite element based forward solver. We modeled the non-contact measurements such that four-wavelength data was collected from four 90-degree-apart views. The results showed that the ratio of the total imaging time to the half-life of the exponentially decaying bioluminescent source was the deciding factor in the reconstruction of the source. It was also demonstrated that a priori knowledge of the source kinetics was required to perform tomographic bioluminescence imaging of short half-life bioluminescent sources and the use of spatial a priori information alone was not adequate.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mehmet Burcin Unlu, Gultekin Gulsen, "Correction for source decay in bioluminescence tomography", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 685010 (19 February 2008); doi: 10.1117/12.768039; https://doi.org/10.1117/12.768039
PROCEEDINGS
6 PAGES


SHARE
Back to Top