19 February 2008 Correction for source decay in bioluminescence tomography
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Time variation of the bioluminescence source can cause artifacts in the tomographic images. We showed that the a priori knowledge of the light kinetics could be used to eliminate these artifacts. We performed two-dimensional simulations. We considered a 40-mm-diameter circular region with an inclusion of 6-mm-diameter located 10-mm away from the center. The measurement data was simulated using a finite element based forward solver. We modeled the non-contact measurements such that four-wavelength data was collected from four 90-degree-apart views. The results showed that the ratio of the total imaging time to the half-life of the exponentially decaying bioluminescent source was the deciding factor in the reconstruction of the source. It was also demonstrated that a priori knowledge of the source kinetics was required to perform tomographic bioluminescence imaging of short half-life bioluminescent sources and the use of spatial a priori information alone was not adequate.
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Mehmet Burcin Unlu, Gultekin Gulsen, "Correction for source decay in bioluminescence tomography", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 685010 (19 February 2008); doi: 10.1117/12.768039; https://doi.org/10.1117/12.768039

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