20 February 2008 Modeling the interaction of lasers and tissue: importance of accounting for time varying electric properties
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Time varying computer models of the interaction of laser light and tissue are very valuable in helping to understand the complexity of the human body and biological tissue. The electrical property of tissue known as permittivity is vital to accurately modeling the interaction of human tissue with lasers. Past laser and RF models have represented the permittivity of the tissue as constant or temperature dependent. This paper presents time dependent permittivity that changes as a result of tissue damage, temperature, blood flow, blood vessels, and tissue property. The models are compared to emphasize the importance of accounting for these different tissue properties. In particular, incorporating the time varying nature of the permittivity of human tissue into the model leads to a significant change seen in tissue damage. An important feature of the model is the feedback loop created between the permittivity, tissue damage, and temperature. The models focus on long time duration applications where the time dependent changes significantly alter the results of the model. The applications for these models lie mostly in the therapeutic area; however, the emphasized points are of consideration for any computer model of the interaction of lasers and tissue.
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Daniel J. Evans, Mark L. Manwaring, "Modeling the interaction of lasers and tissue: importance of accounting for time varying electric properties", Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 68540U (20 February 2008); doi: 10.1117/12.762115; https://doi.org/10.1117/12.762115

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