5 February 2008 Photoacoustic tomography of small-animal and human peripheral joints
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As an emerging imaging technology that combines the merits of both light and ultrasound, photoacoustic tomography (PAT) holds promise for screening and diagnosis of inflammatory joint diseases such as rheumatoid arthritis. In this study, the feasibility of PAT in imaging small-animal joints and human peripheral joints in a noninvasive manner was explored. Ex vivo rat tail and fresh cadaveric human finger joints were imaged. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the joints were visualized successfully. Using light in the near-infrared region, the imaging depth of PAT is sufficient for cross-sectional imaging of a human peripheral joint as a whole organ. PAT, as a novel imaging modality with unique advantages, may contribute significantly to the early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.
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Xueding Wang, Xueding Wang, David L. Chamberland, David L. Chamberland, J. Brian Fowlkes, J. Brian Fowlkes, Paul L. Carson, Paul L. Carson, David A. Jamadar, David A. Jamadar, "Photoacoustic tomography of small-animal and human peripheral joints", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685604 (5 February 2008); doi: 10.1117/12.760811; https://doi.org/10.1117/12.760811

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