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11 March 2008 Discrimination of shear mechanical and optical contrasts in tissue phantoms by use of opto-elastography
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Both mechanical and optical imaging of biological tissue can provide relevant contrasts in terms of biomedical tissue characterization. While ultrasound imaging can easily be performed at depth thanks to the weak scattering of ultrasound in soft tissue, the optical spatial resolution is limited for thick tissue by the strong scattering of light. In this paper, we present a technique involving the optical detection of a transient displacement caused by the acoustic radiation force created at cm depth by a focused intense short ultrasound burst (typically ~millisecond). This localized displacement disturbs the optical paths and allows localizing the information with a resolution dictated by the ultrasound spatial distribution. Using a high-speed camera, our objective was to detect and time-resolve displacements in the focal region and the associated propagation shear waves. Experiments were carried out in attenuating tissue-like media illuminated by a continuous laser source. In this work, we refined the optical detection scheme in order to work with low photons flux, based on two-phase heterodyne interferometry setup. We used tissue-mimicking phantoms with different optical and shear mechanical contrast. We demonstrate that it is possible to detect both types of contrast, and moreover to discriminate between these two types of contrast.
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Khalid Daoudi, Albert-Claude Boccara, and Emmanuel Bossy "Discrimination of shear mechanical and optical contrasts in tissue phantoms by use of opto-elastography", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560F (11 March 2008);

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