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28 February 2008Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies
Ultrasound imaging is the current gold standard for guiding biopsy of prostate. Optoacoustic imaging yields higher
contrast in detection of malignant tissues. The two techniques provide complementary information. We are currently
developing a hybrid laser optoacoustic and ultrasound imaging system for prostate tumor detection (LOUIS-P). The
optoacoustic part consists of a fiber-coupled Q-switched laser operating at either 757 nm or 1064 nm attached to a
commercially-available 128-channel ultrasonic probe modified for optimal detection of optoacoustic signals, a digital
signal processor with 128 independent channels, and software that uses the radial (filtered) backprojection algorithm to
reconstruct tomographic images. We evaluated system-imaging performance using test objects submerged in milky
water, and poly(vinyl-chloride) plastisol tissue phantoms simulating malignant lesions. LOUIS-P demonstrates potential
as a clinical technique for minimally invasive imaging and diagnosis of prostate cancer.
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Mohammad A. Yaseen, H. P.-F. Brecht, Sergey A. Ermilov, Reda R. Gharieb, Andre Conjusteau, Alexander A. Oraevsky, "Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies," Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560T (28 February 2008); https://doi.org/10.1117/12.769881