Investigation of photoacoustic guidance of diffusive optical tomography

John Gamelin; Anastasios Maurudis; Andres Aguirre; Quing Zhu

doi:10.1117/12.769235

28 February 2008 Investigation of photoacoustic guidance of diffusive optical tomography

John Gamelin, Anastasios Maurudis, Andres Aguirre, Quing Zhu

Proceedings Volume 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 68560V (2008) https://doi.org/10.1117/12.769235
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We report the first experimental investigations of photoacoustic guidance of diffusive optical tomography for detection and characterization of optical contrast targets. The hybrid system combined an 8-source, 10-detector reflection mode frequency domain DOT imager with either orthogonal and reflection-geometry photoacoustic systems. The PAT subsystems imaged two-dimensional cross-sections to define centers and radii of regions of interest for a dual-zone mesh DOT imaging algorithm. Phantom absorbers, 1 cm in diameter, of high and low contrast, were spaced 1.5 to 2.5 cm apart at depths ranging from 1 to 2 cm in a turbid medium. Without PAT guidance, the absorber DOT images in many cases were merged and indistinguishable. With PAT guidance, the two targets were well resolved and the reconstructed absorption coefficients improved to 86-130% of the true values. In addition, using both pulse-echo and photoacoustic image detection, the photoacoustic guidance correctly distinguished mechanical from optical contrast providing more specific target information and reconstruction accuracy.

Citation Download Citation

John Gamelin, Anastasios Maurudis, Andres Aguirre, and Quing Zhu "Investigation of photoacoustic guidance of diffusive optical tomography", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560V (28 February 2008); https://doi.org/10.1117/12.769235

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KEYWORDS

Acquisition tracking and pointing

Absorption

Photoacoustic spectroscopy

Transducers

Target detection

Ultrasonography

Optical tomography

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