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28 February 2008 Quantitative imaging of chromophore concentrations using a photoacoustic forward model
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Photoacoustic spectroscopy has been shown to be capable of making non-invasive, spatially resolved measurements of haemodynamic parameters, such as the concentrations of oxy- and deoxyhaemoglobin and blood oxygen saturation. The development of photoacoustic techniques for molecular imaging that go beyond the measurement of haemodynamic parameters has recently become an area of interest. These techniques are aimed at the detection and quantification of for example contrast agents targeted at pathologies such as tumours for diagnostic or therapeutic purposes. This study aimed to validate a model-based inversion scheme by recovering chromophore concentrations from 2D multiwavelength images obtained using a tissue phantom. The inversion scheme employed a complete photoacoustic forward model, which incorporates a model of light transport, a model of acoustic propagation and Fourier transform image reconstruction algorithm. Using the structural information from the measured images, the photoacoustic forward model was used to calculate theoretical multiwavelength photoacoustic images as a function of the concentrations of spatially distributed tissue chromophores and scatters. The chromophore concentrations were determined by fitting the model to the measured images. It was found that concentration ratios of reasonable accuracy were recovered while the absolute concentrations showed significant errors due to light-induced instabilities in the nearinfrared dyes used in the tissue phantom.
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J. Laufer, E. Zhang, B. Cox, and P. Beard "Quantitative imaging of chromophore concentrations using a photoacoustic forward model", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560Z (28 February 2008);

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