28 February 2008 Application of intense ultrasound bursts for quantitative acousto-optic sensing
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Abstract
We have investigated if the application of microsecond length pulses of ultrasound and laser light for AO sensing could result in an improvement of the detection of changes of local absorbances in tissue-mimicking phantoms. An Intralipid-based phantom model, which mimics a blood vessel in human tissue, was used. The detection technique was based on homodyne parallel speckle detection and subsequent image contrast processing. This approach has proved that a spatial resolution of the system of a few millimeters can be obtained and thus, smaller changes in the absorber concentration can be measured. Based on a comparison of experimental data and Monte- Carlo simulations, the quantitative correlation between local absorbances of the phantom and the measured signal has been shown.
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A. Bratchenia, R. Molenaar, R. P. H. Kooyman, "Application of intense ultrasound bursts for quantitative acousto-optic sensing", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685611 (28 February 2008); doi: 10.1117/12.759469; https://doi.org/10.1117/12.759469
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