28 February 2008 Toward functional ultrasound-modulated optical tomography: a phantom study
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We present the feasibility of functional ultrasound-modulated optical tomography (UOT) in tissue phantoms with two optical wavelengths. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observe variations of UOT signal at different optical absorptions. In addition, the results from Monte Carlo simulations highly correlate with the experimental outcomes. By irradiating the sample at two optical wavelengths, we quantitatively estimate the total concentration and the concentration ratio of double dyes in inclusions inside tissue phantoms. Therefore, UOT is potentially able to supply functional imaging of the total concentration and oxygen saturation of hemoglobin non-invasively in biological tissues.
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Chulhong Kim, Chulhong Kim, Lihong V. Wang, Lihong V. Wang, } "Toward functional ultrasound-modulated optical tomography: a phantom study", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68561U (28 February 2008); doi: 10.1117/12.761377; https://doi.org/10.1117/12.761377

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