28 February 2008 Non-invasive detection of osteoporotic bone loss using photothermal radiometry and modulated luminescence
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Osteoporosis is a skeletal disorder characterized by a compromised bone strength predisposing a person to an increased risk of fracture. The early detection of osteoporosis is important to a successful treatment. Current prominent bone densitometry techniques include, among others, Dual Energy X-Ray Absorptiometry (DEXA) and Mechanical Response Tissue Analysis (MRTA). However, DEXA uses ionizing radiation and MRTA results are often unreliable. Simultaneous Photothermal Radiometry (PTR) and Modulated Luminescence (LUM) measurements can be a non-ionizing, noninvasive and reliable alternative to the aforementioned diagnostics techniques. Controlled mineral loss was simulated with sequential etching of a human skull bone. During the experiments, a low-power modulated laser illuminated the sample surface. The absorbed incident optical energy was then re-emitted either non-radiatively, in the form of thermal waves (PTR), or radiatively as lumimescence light emission (LUM). The experimental setup consisted of a semiconductor laser (635 nm, 20 mW), two lock-in amplifiers, a mercury-cadmium-telluride IR detector for PTR, a photodiode for LUM and a computer. A one-dimensional, one-layer theoretical model for LUM and PTR was developed to analyze the experimental data and extract optical and thermal properties of the sample.
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Chi-Hang Kwan, Chi-Hang Kwan, Anna Matvienko, Anna Matvienko, Andreas Mandelis, Andreas Mandelis, } "Non-invasive detection of osteoporotic bone loss using photothermal radiometry and modulated luminescence", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685625 (28 February 2008); doi: 10.1117/12.763844; https://doi.org/10.1117/12.763844

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