In situ photoimmunotherapy for advanced cutaneous melanoma

Mark F. Naylor; Robert E. Nordquist; T. Kent Teague; David A. Adelson; Lisa A. Perry; Wei R. Chen

doi:10.1117/12.764970

28 February 2008 In situ photoimmunotherapy for advanced cutaneous melanoma

Mark F. Naylor, Robert E. Nordquist, T. Kent Teague, David A. Adelson, Lisa A. Perry, Wei R. Chen

Proceedings Volume 6857, Biophotonics and Immune Responses III; 685702 (2008) https://doi.org/10.1117/12.764970
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Currently there are no truly effective treatments for advanced melanoma (surgically unresectable stage III and IV). In situ photoimmunotherapy (ISPI) is a recently developed therapy based on physical and immunological principles that uses lasers in combination with immunostimulants to achieve clinically significant responses in advanced melanoma patients. Results from an ongoing phase I clinical trial suggest that this form of therapy has the highest response rate of any treatment known for advanced melanoma, and in a significant number of subjects, periods of prolonged remissions from the disease can be achieved. ISPI is therefore clearly one of the most promising forms of therapy for this disease and better understanding of the immunological and physical parameters of this treatment will lead to even better clinical results.

Citation Download Citation

Mark F. Naylor, Robert E. Nordquist, T. Kent Teague, David A. Adelson, Lisa A. Perry, and Wei R. Chen "In situ photoimmunotherapy for advanced cutaneous melanoma", Proc. SPIE 6857, Biophotonics and Immune Responses III, 685702 (28 February 2008); https://doi.org/10.1117/12.764970

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