Hormonal component of tumor photodynamic therapy response

Mladen Korbelik; Soroush Merchant

doi:10.1117/12.764023

18 February 2008 Hormonal component of tumor photodynamic therapy response

Mladen Korbelik, Soroush Merchant

Proceedings Volume 6857, Biophotonics and Immune Responses III; 685705 (2008) https://doi.org/10.1117/12.764023
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The involvement of adrenal glucocorticoid hormones in the response of the treatment of solid tumors by photodynamic therapy (PDT) comes from the induction of acute phase response by this modality. This adrenal gland activity is orchestrated through the engagement of the hypothalamic-pituitary-adrenal hormonal axis incited by stress signals emanating from the PDT-treated tumor. Glucocorticoid hormone activity engendered within the context of PDT-induced acute phase response performs multiple important functions; among other involvements they beget acute phase reactant production, systemic neutrophil mobilization, and control the production of inflammation-modulating and immunoregulatory proteins.

Citation Download Citation

Mladen Korbelik and Soroush Merchant "Hormonal component of tumor photodynamic therapy response", Proc. SPIE 6857, Biophotonics and Immune Responses III, 685705 (18 February 2008); https://doi.org/10.1117/12.764023

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