Thermal damage of tissue during near-infrared laser irradiation with assistance of light-absorbing dye

Surya C. Gnyawali; Kelvin Le; Henry Le; James P. Wicksted; Kenneth E. Bartels; Hong Liu; Yichao Chen; Wei R. Chen

doi:10.1117/12.763970

18 February 2008 Thermal damage of tissue during near-infrared laser irradiation with assistance of light-absorbing dye

Surya C. Gnyawali, Kelvin Le, Henry Le, James P. Wicksted, Kenneth E. Bartels, Hong Liu, Yichao Chen, Wei R. Chen

Proceedings Volume 6857, Biophotonics and Immune Responses III; 68570O (2008) https://doi.org/10.1117/12.763970
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The selective photothermal-tissue interaction using dye enhancement has been proven to be effective in minimizing the peripheral normal tissue damage during cancer treatment. It is important that the tissue-thermal damage be analyzed and the damage rate process be estimated before the photothermal-immunotherapy for cancer treatment. In this study, we have used the EMT6 mouse tumor model for the laser-tumor treatment with a simultaneous surface temperature measurement using infrared thermography. The images acquired were processed to obtain the temperature profiles. The saturation temperature and corresponding time of irradiation from the temporal profiles were used to calculate the damage parameter using Arrhenius rate process equation. The damage parameters obtained from six mice were compared. Our results of in vivo study show that the damage analyses agree with the previous in vitro study on skins.

Citation Download Citation

Surya C. Gnyawali, Kelvin Le, Henry Le, James P. Wicksted, Kenneth E. Bartels, Hong Liu, Yichao Chen, and Wei R. Chen "Thermal damage of tissue during near-infrared laser irradiation with assistance of light-absorbing dye", Proc. SPIE 6857, Biophotonics and Immune Responses III, 68570O (18 February 2008); https://doi.org/10.1117/12.763970

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