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28 February 2008 Real-time monitoring of chemical and structural changes induced by light irradiation of cells and tissues
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Abstract
We report on a novel approach to study cells and tissues exposed to laser radiation. By using a tightly focused laser beam, a selected area of a cell or a tissue can be selectively irradiated, and the results of this interaction can be immediately interrogated using Raman confocal microscopy. We present our experimental results for skin and eye tissues and individual retinal pigmented epithelium cells demonstrating a great potential of this new research paradigm.
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Vladislav V. Yakovlev, Robert J. Thomas, Gary Noojin, and Michael Denton "Real-time monitoring of chemical and structural changes induced by light irradiation of cells and tissues", Proc. SPIE 6859, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI, 68590E (28 February 2008); https://doi.org/10.1117/12.764292
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