Toward single-molecule detection with very compact DNA sequencer based on single-photon avalanche diode array

Ivan Rech; Stefano Marangoni; Angelo Gulinatti; Massimo Ghioni; Sergio Cova

doi:10.1117/12.764508

21 February 2008 Toward single-molecule detection with very compact DNA sequencer based on single-photon avalanche diode array

Ivan Rech, Stefano Marangoni, Angelo Gulinatti, Massimo Ghioni, Sergio Cova

Author Affiliations +

Proceedings Volume 6862, Single Molecule Spectroscopy and Imaging; 68620D (2008) https://doi.org/10.1117/12.764508
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The development of a very-compact DNA sequencer instrument based on Single Photon Avalanche Diode (SPAD) for microchip electrophoresis is here reported. The planar epitaxial SPAD combines the typical advantages of microelectronic devices with high sensitivity. We present a miniaturized system based on a custom array of SPAD, purposely designed to be compatible with Amersham Biosciences commercial markers. This system is the first example of very compact, ultra-sensitive, portable and low cost DNA sequencer. It may represent a breakthrough in DNA sequencing system and open the way to the development of a new category of portable low-cost apparatus.

Citation Download Citation

Ivan Rech, Stefano Marangoni, Angelo Gulinatti, Massimo Ghioni, and Sergio Cova "Toward single-molecule detection with very compact DNA sequencer based on single-photon avalanche diode array", Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620D (21 February 2008); https://doi.org/10.1117/12.764508

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