22 February 2008 Gold nanoshells for OCT imaging contrast: From model to in-vivo study
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We have investigated the effect of application of gold nanoshells with a 150 nm silica core size and 25 nm thick gold coating on optical properties of skin. We have analyzed the possibility of using these particles as a contrasting agent for optical coherence tomography (OCT). A set of Monte Carlo calculations was performed in order to simulate the images of skin before and after application of the nanoshells for a skin model close to that in vivo. We investigated the mechanisms of boundary contrasting between tissue layers with different optical properties in the presence of gold nanoshells on two-layer agar gel phantom. Gold nanoshells were also applied on the skin surface in vivo. Gold-silica nanoshells caused an increase in the intensity of OCT signal, brightness of the superficial part of the dermis, contrast between dermis layers and contrast of hair follicles and glands in the OCT image. The contrasting effects of the gold nanoshells lasted up to 24 hours of observation.
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E. V. Zagaynova, E. V. Zagaynova, M. V. Shirmanova, M. V. Shirmanova, A. G. Orlova, A. G. Orlova, I. V. Balalaeva, I. V. Balalaeva, M. Yu. Kirillin, M. Yu. Kirillin, V. A. Kamensky, V. A. Kamensky, M. L. Bugrova, M. L. Bugrova, M. A Sirotkina, M. A Sirotkina, } "Gold nanoshells for OCT imaging contrast: From model to in-vivo study", Proc. SPIE 6865, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V, 68650K (22 February 2008); doi: 10.1117/12.763004; https://doi.org/10.1117/12.763004

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