Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy L. Oldenburg; Matthew N. Hansen; Alexander Wei; Stephen A. Boppart M.D.

doi:10.1117/12.761886

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22 February 2008 Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei, Stephen A. Boppart M.D.

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Proceedings Volume 6867, Molecular Probes for Biomedical Applications II; 68670E (2008) https://doi.org/10.1117/12.761886
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Plasmon-resonant gold nanorods have been demonstrated recently as contrast agents for optical coherence tomography (OCT). To evaluate their ability to produce contrast in a structurally heterogeneous environment, nanorods were injected at discrete locations into an excised sample of human breast invasive ductal carcinoma. The distribution of nanorods within the tissue was revealed using spectroscopic OCT imaging techniques, by analyzing the evolution of the backscattered light spectrum over tissue depth. We compare a variety of signal processing methods including spatial averaging and least-squares fitting to the a priori extinction spectrum of the nanorods, with the goal of optimizing the detection sensitivity to the nanorods in these tissues. Because nanorods can be conjugated with proteins specific to biomolecular targets, they may potentially be used with these imaging methods to provide molecular contrast in human tissues.

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Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei, and Stephen A. Boppart M.D. "Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors", Proc. SPIE 6867, Molecular Probes for Biomedical Applications II, 68670E (22 February 2008); https://doi.org/10.1117/12.761886

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