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21 February 2008 Gel phantom in selective laser phototherapy
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Tissue-simulating gel phantoms have been used in selective laser photothermal interaction. The gelatin phantom provides a uniform tissue-simulating medium for analyzing thermal performance under laser radiation. The gelatin phantom gel is used particularly in measurements of thermal reactions in laser thermology. The gelatin phantom is made from gelatin and Liposyn. A special gel sphere with Indocyanine Green (ICG) laser absorption enhancement dye is embedded in normal gel to simulate the dye-enhanced tumor in normal tissue. The concentration of ICG within the dye sphere is optimized using simulation for selective phototherapy. As a first attempt, the concentration of ICG and laser power density was optimized using a temperature ratio of target tissue versus surrounding tissue. The gel thermal performance is also monitored using MRI thermology imaging technology. The thermal imaging shows in vivo, 3D temperature mapping inside the gel. The study of thermal distribution using gel phantom provides information to guide the future selective laser photothermal thermal therapy.
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Yichao Chen, Christopher A. Bailey, Thomas M. Cowan, Feng Wu, Hong Liu, Rheal A. Towner, and Wei R. Chen "Gel phantom in selective laser phototherapy", Proc. SPIE 6870, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue, 687008 (21 February 2008);

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