Development of an evaporation-based microfluidic sample concentrator

Nigel R. Sharma; Anatoly Lukyanov; Ron L. Bardell; Lynn Seifried; Mingchao Shen

doi:10.1117/12.764100

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13 February 2008 Development of an evaporation-based microfluidic sample concentrator

Nigel R. Sharma, Anatoly Lukyanov, Ron L. Bardell, Lynn Seifried, Mingchao Shen

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Proceedings Volume 6886, Microfluidics, BioMEMS, and Medical Microsystems VI; 68860R (2008) https://doi.org/10.1117/12.764100
Event: MOEMS-MEMS 2008 Micro and Nanofabrication, 2008, San Jose, California, United States

Abstract

MicroPlumbers Microsciences LLC, has developed a relatively simple concentrator device based on isothermal evaporation. The device allows for rapid concentration of dissolved or dispersed substances or microorganisms (e.g. bacteria, viruses, proteins, toxins, enzymes, antibodies, etc.) under conditions gentle enough to preserve their specific activity or viability. It is capable of removing of 0.8 ml of water per minute at 37°C, and has dimensions compatible with typical microfluidic devices. The concentrator can be used as a stand-alone device or integrated into various processes and analytical instruments, substantially increasing their sensitivity while decreasing processing time. The evaporative concentrator can find applications in many areas such as biothreat detection, environmental monitoring, forensic medicine, pathogen analysis, and agricultural industrial monitoring. In our presentation, we describe the design, fabrication, and testing of the concentrator. We discuss multiphysics simulations of the heat and mass transport in the device that we used to select the design of the concentrator and the protocol of performance testing. We present the results of experiments evaluating water removal performance.

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Nigel R. Sharma, Anatoly Lukyanov, Ron L. Bardell, Lynn Seifried, and Mingchao Shen "Development of an evaporation-based microfluidic sample concentrator", Proc. SPIE 6886, Microfluidics, BioMEMS, and Medical Microsystems VI, 68860R (13 February 2008); https://doi.org/10.1117/12.764100

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