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18 March 2008 Low-dose dual-energy computed tomography for PET attenuation correction with statistical sinogram restoration
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Abstract
Dual-energy (DE) X-ray computed tomography (CT) has been proposed as an useful tool in various applications. One promising application is DECT with low radiation doses used for attenuation correction in positron emission tomography (PET). In low-dose DECT, conventional methods for sinogram decomposition have been based on logarithmic transformations and ignored noise properties, leading to very noisy component sinogram estimates. In this paper, we propose two novel sinogram restoration methods that are statistically motivated; penalized weighted least square (PWLS) and penalized likelihood (PL), producing less noisy component sinogram estimates for low-dose DECT than the conventional approaches. The restored component sinograms can improve attenuation correction, thus allowing better image quality in PET. Experiments with a digital phantom indicate that the proposed methods produce less noisy sinograms, reconstructed images, and attenuation correction factors (ACF) than the conventional one, showing promise for CT-based attenuation correction in emission tomography.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Joonki Noh, Jeffrey A. Fessler, and Paul E. Kinahan "Low-dose dual-energy computed tomography for PET attenuation correction with statistical sinogram restoration", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691312 (18 March 2008); https://doi.org/10.1117/12.769855
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