25 March 2008 Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography
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Abstract
To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.
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Yakov Nesterets, Yakov Nesterets, Tim Gureyev, Tim Gureyev, Andrew Stevenson, Andrew Stevenson, Andrew Pogany, Andrew Pogany, Steve Wilkins, Steve Wilkins, Russell Kincaid, Russell Kincaid, Hongwei Ye, Hongwei Ye, Levon Vogelsang, Levon Vogelsang, Edward Lipson, Edward Lipson, Ioana Coman, Ioana Coman, Sylvain Fourmaux, Sylvain Fourmaux, Jean-Claude Kieffer, Jean-Claude Kieffer, Andrzej Krol, Andrzej Krol, } "Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69133Z (25 March 2008); doi: 10.1117/12.772761; https://doi.org/10.1117/12.772761
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