18 March 2008 A dual micro-CT system for small animal imaging
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Proceedings Volume 6913, Medical Imaging 2008: Physics of Medical Imaging; 691342 (2008); doi: 10.1117/12.772303
Event: Medical Imaging, 2008, San Diego, California, United States
Abstract
Micro-CT is a non-invasive imaging modality usually used to assess morphology in small animals. In our previous work, we have demonstrated that functional micro-CT imaging is also possible. This paper describes a dual micro-CT system with two fixed x-ray/detectors developed to address such challenging tasks as cardiac or perfusion studies in small animals. A two-tube/detector system ensures simultaneous acquisition of two projections, thus reducing scanning time and the number of contrast injections in perfusion studies by a factor of two. The system is integrated with software developed in-house for cardio-respiratory monitoring and gating. The sampling geometry was optimized for 88 microns in such a way that the geometric blur of the focal spot matches the Nyquist sample at the detector. A geometric calibration procedure allows one to combine projection data from the two chains into a single reconstructed volume. Image quality was measured in terms of spatial resolution, uniformity, noise, and linearity. The modulation transfer function (MTF) at 10% is 3.4 lp/mm for single detector reconstructions and 2.3 lp/mm for dual tube/detector reconstructions. We attribute this loss in spatial resolution to the compounding of slight errors in the separate single chain calibrations. The dual micro-CT system is currently used in studies for morphological and functional imaging of both rats and mice.
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C. T. Badea, S. Johnston, B. Johnson, M. Lin, L. W. Hedlund, G. Allan Johnson, "A dual micro-CT system for small animal imaging", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691342 (18 March 2008); doi: 10.1117/12.772303; https://doi.org/10.1117/12.772303
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KEYWORDS
Imaging systems

Sensors

Calibration

Modulation transfer functions

Iodine

X-rays

Image quality

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