20 March 2008 MR-guided catheter-based excitation emission optical spectroscopy for in vivo tissue characterization
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Excitation emission spectroscopy (EES) has been used in the past to characterize many different types of tissue. This technique uses multiple excitation wavelengths and samples a complete optical spectrum for each, yielding an excitation-emission matrix (EEM). Upon study of the EEM, it is possible to determine the presence of multiple optical contrast agents since these dyes can have characteristic spectra that can be separated. Here, we demonstrate EES specifically designed for use in conjunction with MR. This EES is applied with an in-suite control setup that permits real-time navigation, utilizing active MR tracking catheters, and providing a platform for MR-guided tissue characterization. The EES system is used in a demonstration experiment to highlight MR imaging, MR guidance in conjunction with a catheter-based optical measurement.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
D. A. Herzka, D. A. Herzka, M. S. Kotys, M. S. Kotys, S. Krueger, S. Krueger, B. J. Traughber, B. J. Traughber, J. Heroux, J. Heroux, A. M. Gharib, A. M. Gharib, J. Ohayon, J. Ohayon, S. Weiss, S. Weiss, R. I. Pettigrew, R. I. Pettigrew, B. J. Wood, B. J. Wood, } "MR-guided catheter-based excitation emission optical spectroscopy for in vivo tissue characterization", Proc. SPIE 6918, Medical Imaging 2008: Visualization, Image-Guided Procedures, and Modeling, 69181U (20 March 2008); doi: 10.1117/12.770758; https://doi.org/10.1117/12.770758

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