A novel ultrasonic method for measuring breast density and breast cancer risk

Carri K. Glide-Hurst; Neb Duric; Peter J. Littrup

doi:10.1117/12.772365

13 March 2008 A novel ultrasonic method for measuring breast density and breast cancer risk

Carri K. Glide-Hurst, Neb Duric, Peter J. Littrup

Proceedings Volume 6920, Medical Imaging 2008: Ultrasonic Imaging and Signal Processing; 69200Q (2008) https://doi.org/10.1117/12.772365
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

Women with high mammographic breast density are at 4- to 6-fold increased risk of developing breast cancer compared to women with fatty breasts. However, current breast density estimations rely on mammography, which cannot provide accurate volumetric breast representation. Therefore, we explored two techniques of breast density evaluation via ultrasound tomography. A sample of 93 patients was imaged with our clinical prototype; each dataset contained 45-75 tomograms ranging from near the chest wall through the nipple. Whole breast acoustic velocity was determined by creating image stacks and evaluating the sound speed frequency distribution. Ultrasound percent density (USPD) was determined by segmenting high sound speed areas from each tomogram using k-means clustering, integrating over the entire breast, and dividing by total breast area. Both techniques were independently evaluated using two mammographic density measures: (1) qualitative, determined by a radiologist's visual assessment using BI-RADS Categories, and (2) quantitative, via semi-automatic segmentation to calculate mammographic percent density (MPD) for craniocaudal and medio-lateral oblique mammograms. ~140 m/s difference in acoustic velocity was observed between fatty and dense BI-RADS Categories. Increased sound speed was found with increased BI-RADS Category and quantitative MPD. Furthermore, strong positive associations between USPD, BI-RADS Category, and calculated MPD were observed. These results confirm that utilizing sound speed, both for whole-breast evaluation and segmenting locally, can be implemented to evaluate breast density.

Citation Download Citation

Carri K. Glide-Hurst, Neb Duric, and Peter J. Littrup "A novel ultrasonic method for measuring breast density and breast cancer risk", Proc. SPIE 6920, Medical Imaging 2008: Ultrasonic Imaging and Signal Processing, 69200Q (13 March 2008); https://doi.org/10.1117/12.772365

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available