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2 May 2008 Infrared imaging for tumor detection using antibodies conjugated magnetic nanoparticles
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Thermography is a well known approach for cost effective early detection of concourse tumors. However, till now - more than 5 decades after its introduction - it is not considered as a primary tool for cancer early detection, mainly because its poor performance compared to other techniques. This work offers a new thermographic approach for tumor detection which is based on the use of antibody conjugated magnetic nanoparticles ("MNP") as a tumor specific marker. Wename this method "Thermal Beacon Thermography" ("TBT"), and it has the potential to provide considerable advantages over conventional thermographic approach. TBT approach is based on the fact that MNP are producing heat when subjected to an alternating magnetic field ("AMF"). Once these particles are injected to the patient blood stream, they specifically accumulate at the tumor site, providing a local heat source at the tumor that can be activated and deactivated by external control. This heat source can be used as a "thermal beacon" in order to detect and locate tumor by detecting temperature changes at the skin surface using an IR camera and comparing them to a set of pre-calculated numerical predictions. Experiments were conducted using an in vitro tissue model together with industrial inductive heating system and an IR camera. The results shows that this approach can specifically detect small tumor phantom (D=1.5mm) which was embedded below the surface of the tissue phantom.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Arie Levy and Israel Gannot "Infrared imaging for tumor detection using antibodies conjugated magnetic nanoparticles", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699108 (2 May 2008);

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