9 May 2008 A novel nano-photonics biosensor concept for rapid molecular diagnostics
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Abstract
We present a novel nano-photonics biosensor concept that offers an ultra-high surface specificity and excellent suppression of background signals due to the sample fluid on top of the biosensor. In our contribution, we will briefly discuss the operation principle and fabrication of the biosensor, followed by a more detailed discussion on the experimentally determined performance parameters. Recent results on detection of fluorescently labeled molecules in a highly fluorescent background will be shown, and we will give an outlook on real-time detection of bio-molecules such as proteins and nucleic acids.
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Dion J. W. Klunder, Maarten M. J. W. van Herpen, Aleksey Kolesnychenko, Eefje Hornix, Nicoletta Kahya, Ruth de Boer, Henk Stapert, "A novel nano-photonics biosensor concept for rapid molecular diagnostics", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 69910P (9 May 2008); doi: 10.1117/12.781340; https://doi.org/10.1117/12.781340
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