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2 May 2008 Non-invasive dry mass determination and monitoring at the single cell level with digital holographic microscopy
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Abstract
Digital holography microscopy (DHM) is an optical microscopy technique which allows recording non-invasively the phase shift induced by living cells with nanometric sensitivity. Here, we exploit the phase signal as an indicator of dry mass (related to the protein concentration). This parameter allows monitoring the protein production rate and its evolution during the cell cycle.
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Benjamin Rappaz, Elena Cano, Jonas Kühn, Tristan Colomb, Christian Depeursinge, Pierre J. Magistretti, and Pierre Marquet "Non-invasive dry mass determination and monitoring at the single cell level with digital holographic microscopy", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699111 (2 May 2008); https://doi.org/10.1117/12.781565
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