Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis

Yasser R. Hijazi; Cemre Kortun; Dizem Arifler

doi:10.1117/12.781378

2 May 2008 Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis

Yasser R. Hijazi, Cemre Kortun, Dizem Arifler

Proceedings Volume 6991, Biophotonics: Photonic Solutions for Better Health Care; 699129 (2008) https://doi.org/10.1117/12.781378
Event: SPIE Photonics Europe, 2008, Strasbourg, France

Abstract

Monte Carlo (MC) modeling is widely used to study photon transport in tissues but is generally performed using simplified phase functions that only approximate the angular scattering probability distribution of microscopic tissue constituents such as cells. Finite-Difference Time-Domain (FDTD) modeling has recently provided a flexible approach to compute scattering phase functions for realistic cell geometries. We present a computational framework that combines MC and FDTD modeling and allows random sampling of scattering directions from cellular phase functions computed using the FDTD method. Combined MC/FDTD simulation results indicate that the exact form of the phase function used is an important factor in determining the modeled optical response of tissues. Subtle differences in angular scattering probability distribution can lead to significant changes in detected reflectance intensity and the extent of these changes depends on the specific range of scattering angles to which a given optical sensor design is most sensitive.

Citation Download Citation

Yasser R. Hijazi, Cemre Kortun, and Dizem Arifler "Combined Monte Carlo and finite-difference time-domain modeling for biophotonic analysis", Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699129 (2 May 2008); https://doi.org/10.1117/12.781378

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KEYWORDS

Finite-difference time-domain method

Scattering

Tissues

Optical fibers

Reflectivity

Monte Carlo methods

Refractive index

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